Effects of Exercise on ASC Methylation and IL-1 Cytokines in Heart Failure.

ABSTRACT: INTRODUCTION/PURPOSE:Inflammation contributes to heart failure (HF) progression and the interleukin (IL)-1 cytokine IL-1β is implicated in this process. The adaptor protein apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is necessary for inflammasome activation of IL-1β. Lower ASC methylation is associated with worse outcomes in HF. The purpose of this study was to examine the effects of exercise on changes in ASC methylation and activation of the IL-1 family cytokine IL-1β in persons with HF. METHODS:Participants (N = 54) were randomized to receive exercise intervention (n = 38) or attention control (n = 16) for 3 months. Percent methylation of the ASC gene, plasma IL-1β, and ASC mRNA and were obtained at baseline, 3 months, and 6 months. RESULTS:ASC

SUBMITTER: Butts B 

PROVIDER: S-EPMC6095733 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature