Efficacy of Testosterone plus NASA Exercise Countermeasures during Head-Down Bed Rest.

ABSTRACT:

Introduction

Prolonged confinement to head-down bed rest (HDBR) results in musculoskeletal losses similar to those observed during long-duration space flight. Exercise countermeasures by themselves have not completely prevented the deleterious losses in muscle mass or function in HDBR or space flight.

Purpose

The objective was to investigate the safety and efficacy of intermittent, low-dose testosterone treatment in conjunction with NASA exercise (SPRINT) countermeasures during 70 d of 6° HDBR.

Methods

Healthy men (35 ± 8 yr) were randomized into one of three groups that remained inactive (CON) or performed exercise 6 d·wk in addition to receiving either placebo (PEX) or testosterone treatment (TEX, 100 mg·wk). Testosterone/placebo injections were administered once a

SUBMITTER: Dillon EL 

PROVIDER: S-EPMC6095739 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature