Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response.

ABSTRACT: Tumour cells evade immune surveillance by upregulating the surface expression of programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 (PD-1) receptor on T cells to elicit the immune checkpoint response^1,2. Anti-PD-1 antibodies have shown remarkable promise in treating tumours, including metastatic melanoma^2-4. However, the patient response rate is low^4,5. A better understanding of PD-L1-mediated immune evasion is needed to predict patient response and improve treatment efficacy. Here we report that metastatic melanomas release extracellular vesicles, mostly in the form of exosomes, that carry PD-L1 on their surface. Stimulation with interferon-γ (IFN-γ) increases the amount of PD-L1 on these vesicles, which suppresses the function of C

SUBMITTER: Chen G 

PROVIDER: S-EPMC6095740 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature