A Novel Translational Model of Spinal Cord Injury in Nonhuman Primate.

ABSTRACT: Spinal cord injuries (SCI) lead to major disabilities affecting > 2.5 million people worldwide. Major shortcomings in clinical translation result from multiple factors, including species differences, development of moderately predictive animal models, and differences in methodologies between preclinical and clinical studies. To overcome these obstacles, we first conducted a comparative neuroanatomical analysis of the spinal cord between mice, Microcebus murinus (a nonhuman primate), and humans. Next, we developed and characterized a new model of lateral spinal cord hemisection in M. murinus. Over a 3-month period after SCI, we carried out a detailed, longitudinal, behavioral follow-up associated with in vivo magnetic resonance imaging (¹H-MRI) monitoring. Then, we compared lesio

SUBMITTER: Le Corre M 

PROVIDER: S-EPMC6095780 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature