An essential role for the nuclear protein Akirin2 in mouse limb interdigital tissue regression.

ABSTRACT: The regulation of interdigital tissue regression requires the interplay of multiple spatiotemporally-controlled morphogen gradients to ensure proper limb formation and release of individual digits. Disruption to this process can lead to a number of limb abnormalities, including syndactyly. Akirins are highly conserved nuclear proteins that are known to interact with chromatin remodelling machinery at gene enhancers. In mammals, the analogue Akirin2 is essential for embryonic development and critical for a wide variety of roles in immune function, meiosis, myogenesis and brain development. Here we report a critical role for Akirin2 in the regulation of interdigital tissue regression in the mouse limb. Knockout of Akirin2 in limb epithelium leads to a loss of interdigital cell death and an i

SUBMITTER: Bosch PJ 

PROVIDER: S-EPMC6095873 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature