HbA_1c Measured in the First Trimester of Pregnancy and the Association with Gestational Diabetes.

ABSTRACT: We aimed to examine the prospective association between first trimester HbA_1c and gestational diabetes (GDM) and explore the utility of HbA_1c for prediction of GDM. We used data from a case-control study within the prospective NICHD Fetal Growth Studies-Singleton Cohort (2009-2013), which enrolled 2,802 women at 12 U.S. clinical centers. HbA_1c was measured in GDM cases (n = 107) and matched controls (n = 214) targeted at 8-13, 16-22, 24-29, and 34-37 gestational weeks. We excluded women with HbA_1c ≥ 6.5% (48 mmol/mol) at enrollment (n = 3) or who had a hemoglobin variant (n = 6). At 8-13 gestational weeks, women who later developed GDM had significantly higher HbA_1c (5.3[standard deviation 0.3]%; 34[4]mmol/mol) than women without GDM (

SUBMITTER: Hinkle SN 

PROVIDER: S-EPMC6095876 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature