Translation of Hepatitis A Virus IRES Is Upregulated by a Hepatic Cell-Specific Factor.

ABSTRACT: Many viruses strongly prefer to infect certain cell types, a phenomenon known as "tropism." Understanding tropism's molecular basis is important for the design of vaccines and antiviral therapy. A common mechanism involves viral protein interactions with cell-specific surface receptors, but intracellular mechanisms involving translation have also been described. In this report, we focus on Hepatitis A Virus (HAV) tissue tropism from the standpoint of the translational machinery. HAV genomic RNA, like other positive stranded RNA viruses, is devoid of a cap structure and its translation is driven by highly structured RNA sequences termed internal ribosome entry site (IRES) in the 5' untranslated region (UTR). Unlike most viral IRESs, HAV IRES-mediated translation requires eIF4E and the 3' en

SUBMITTER: Sadahiro A 

PROVIDER: S-EPMC6095998 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature