Design, synthesis, and biological evaluation of m-amidophenol derivatives as a new class of antitubercular agents.

ABSTRACT: A series of m-amidophenol derivatives (6a-6l, 7a-7q, 9a, 9b, 12a-12c, 14 and 15) were designed and synthesized. Their antitubercular activities were evaluated in vitro against M. tuberculosis strains H37Ra and H37Rv and clinically isolated multidrug-resistant M. tuberculosis strains. Ten compounds displayed minimal inhibitory concentrations (MICs) against M. tuberculosis H37Ra below 2.5 μg mL^-1 and 6g was the most active compound (MIC = 0.625 μg mL^-1). Compounds 6g and 7a also showed potent inhibitory activity against M. tuberculosis H37Rv (MIC = 0.39 μg mL^-1) and several clinically isolated multidrug-resistant M. tuberculosis strains (MIC

SUBMITTER: Zhang NN 

PROVIDER: S-EPMC6096355 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature