Magnesium deficiency prevents high-fat-diet-induced obesity in mice.

ABSTRACT:

Aims/hypothesis

Hypomagnesaemia (blood Mg²⁺ <0.7 mmol/l) is a common phenomenon in individuals with type 2 diabetes. However, it remains unknown how a low blood Mg²⁺ concentration affects lipid and energy metabolism. Therefore, the importance of Mg²⁺ in obesity and type 2 diabetes has been largely neglected to date. This study aims to determine the effects of hypomagnesaemia on energy homeostasis and lipid metabolism.

Methods

Mice (n = 12/group) were fed either a low-fat diet (LFD) or a high-fat diet (HFD) (10% or 60% of total energy) in combination with a normal- or low-Mg²⁺ content (0.21% or 0.03% wt/wt) for 17 weeks. Metabolic cages were used to investigate food intake, energy expenditure and respiration. Blood and tissues were

SUBMITTER: Kurstjens S 

PROVIDER: S-EPMC6096631 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature