Identification and annotation of bovine granzyme genes reveals a novel granzyme encoded within the trypsin-like locus.

ABSTRACT: Granzymes are a family of serine proteases found in the lytic granules of cytotoxic T lymphocytes and natural killer (NK) cells, which are involved in killing of susceptible target cells. Most information on granzymes and their enzymatic specificities derive from studies in humans and mice. Although granzymes shared by both species show a high level of conservation, the complement of granzyme genes differs between the species. The aim of this study was to identify granzyme genes expressed in cattle, determine their genomic locations and analyse their sequences to predict likely functional specificities. Orthologues of the five granzyme genes found in humans (A, B, H, K and M) were identified, as well a novel gene designated granzyme O, most closely related to granzyme A. An orthologue of g

SUBMITTER: Yang J 

PROVIDER: S-EPMC6096847 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature