SuperDCA for genome-wide epistasis analysis.

ABSTRACT: The potential for genome-wide modelling of epistasis has recently surfaced given the possibility of sequencing densely sampled populations and the emerging families of statistical interaction models. Direct coupling analysis (DCA) has previously been shown to yield valuable predictions for single protein structures, and has recently been extended to genome-wide analysis of bacteria, identifying novel interactions in the co-evolution between resistance, virulence and core genome elements. However, earlier computational DCA methods have not been scalable to enable model fitting simultaneously to 10⁴-10⁵ polymorphisms, representing the amount of core genomic variation observed in analyses of many bacterial species. Here, we introduce a novel inference method (SuperDCA) t

SUBMITTER: Puranen S 

PROVIDER: S-EPMC6096938 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature