Real-Time Cellular Cytochrome C Monitoring through an Optical Microfiber: Enabled by a Silver-Decorated Graphene Nanointerface.

ABSTRACT: The translocation of cytochrome c (cyt c) from mitochondria and out of cell is an important signal of cell apoptosis. Monitoring this process extracellularly without invasion and cytotoxicity to cells is of great importance to understand certain diseases at the cellular level; however, it requires sensors with ultrahigh sensitivity and miniature size. This study reports an optical microfiber aptasensor with a silver-decorated graphene (Ag@RGO) nanointerface for real-time cellular cyt c monitoring. Owing to an interfacial sensitization effect coupled with the plasmonic electromagnetic enhancement of silver nanoparticles and chemical enhancement of graphene platforms, which enhances the energy density on microfiber surface obviously, the lowest limit of detection achieved is 6.82 × 10^-1

SUBMITTER: Li H 

PROVIDER: S-EPMC6096990 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature