Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action.

ABSTRACT: Bioactive natural products have evolved to inhibit specific cellular targets and have served as lead molecules for health and agricultural applications for the past century^1-3. The post-genomics era has brought a renaissance in the discovery of natural products using synthetic-biology tools^4-6. However, compared to traditional bioactivity-guided approaches, genome mining of natural products with specific and potent biological activities remains challenging⁴. Here we present the discovery and validation of a potent herbicide that targets a critical metabolic enzyme that is required for plant survival. Our approach is based on the co-clustering of a self-resistance gene in the natural-product biosynthesis gene cluster^7-9, which provides insight int

SUBMITTER: Yan Y 

PROVIDER: S-EPMC6097235 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature