Low serum gastrin associated with ER⁺ breast cancer development via inactivation of CCKBR/ERK/P65 signaling.

ABSTRACT:

Background

Gastrin is an important gastrointestinal hormone produced primarily by G-cells in the antrum of the stomach. It normally regulates gastric acid secretion and is implicated in a number of human disease states, but how its function affects breast cancer (BC) development is not documented. The current study investigated the suppressive effects of gastrin on BC and its underlying mechanisms.

Methods

Serum levels of gastrin were measured by enzyme-linked immunosorbent assay (ELISA) and correlation between gastrin level and development of BC was analyzed by chi-square test. Inhibitory effects of gastrin on BC were investigated by CCK-8 assay and nude mice models. Expressions of CCKBR/ERK/P65 in BC patients were determined through immunohistochemistry (IHC) and Western b

SUBMITTER: Meng LL 

PROVIDER: S-EPMC6097285 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature