Partial factorial trials: comparing methods for statistical analysis and economic evaluation.

ABSTRACT:

Background

Partial factorial trials compare two or more pairs of treatments on overlapping patient groups, randomising some (but not all) patients to more than one comparison. The aims of this research were to compare different methods for conducting and analysing economic evaluations on partial factorial trials and assess the implications of considering factors simultaneously rather than drawing independent conclusions about each comparison.

Methods

We estimated total costs and quality-adjusted life years (QALYs) within 10 years of surgery for 2252 patients in the Knee Arthroplasty Trial who were randomised to one or more comparisons of different surgical types. We compared three analytical methods: an "at-the-margins" analysis including all patients randomised to each comp

SUBMITTER: Dakin HA 

PROVIDER: S-EPMC6097309 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature