Intake of folate and other nutrients related to one-carbon metabolism and risk of cutaneous melanoma among US women and men.

ABSTRACT:

Background

Nutrients involved in one-carbon metabolism - folate, vitamins B6 and B12, methionine, choline, and betaine - have been inversely associated with multiple cancer sites and may be related to skin cancer. However, there is a lack of research on the association between intake of these nutrients and cutaneous melanoma risk. The aim of this study was to examine the associations between intake of one-carbon metabolism nutrients and cutaneous melanoma risk in two large prospective cohorts.

Methods

The cohorts included 75,311 white women and 48,523 white men. Nutrient intake was assessed repeatedly by food frequency questionnaires and self-reported supplement use. We used Cox proportional hazards regression to estimate multivariable-adjusted hazard ratios (HRs) and 95% co

SUBMITTER: Dhana A 

PROVIDER: S-EPMC6097627 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature