Using Base Rate of Low Scores to Identify Progression from Amnestic Mild Cognitive Impairment to Alzheimer's Disease.

ABSTRACT:

Objectives

To investigate the implications of obtaining one or more low scores on a battery of cognitive tests on diagnosing mild cognitive impairment (MCI).

Design

Observational longitudinal study.

Setting

Alzheimer's Disease Neuroimaging Initiative.

Participants

Normal controls (NC, n = 280) and participants with MCI (n = 415) according to Petersen criteria were reclassified using the Jak/Bondi criteria and number of impaired tests (NIT) criteria.

Measurements

Diagnostic statistics and hazard ratios of progression to Alzheimer's disease (AD) were compared according to diagnostic criteria.

Results

The NIT criteria were a better predictor of progression to AD than the Petersen or Jak/Bondi criteria, with optimal sensitivity, specificity, and posit

SUBMITTER: Oltra-Cucarella J 

PROVIDER: S-EPMC6097891 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature