Non-contrast MR imaging of blood-brain barrier permeability to water.

ABSTRACT:

Purpose

Many brain diseases are associated with an alteration in blood-brain barrier (BBB) and its permeability. Current methods using contrast agent are primarily sensitive to major leakage of BBB to macromolecules, but may not detect subtle changes in BBB permeability. The present study aims to develop a novel non-contrast MRI technique for the assessment of BBB permeability to water.

Methods

The central principle is that by measuring arterially labeled blood spins that are drained into cerebral veins, water extraction fraction (E) and permeability-surface-area product (PS) of BBB can be determined. Four studies were performed. We first demonstrated the proof-of-principle using conventional ASL with very long post-labeling delays (PLD). Next, a new sequence, dubbed water-e

SUBMITTER: Lin Z 

PROVIDER: S-EPMC6097906 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature