Quantifying the effects of hydration on corneal stiffness with noncontact optical coherence elastography.

ABSTRACT:

Purpose

To quantify the effects of the hydration state on the Young's modulus of the cornea.

Setting

Biomedical Optics Laboratory, University of Houston, Houston, Texas, USA.

Design

Experimental study.

Methods

Noncontact, dynamic optical coherence elastography (OCE) measurements were taken of in situ rabbit corneas in the whole eye-globe configuration (n = 10) and at an artificially controlled intraocular pressure of 15 mm Hg. Baseline OCE measurements were taken by topically hydrating the corneas with saline for 1 hour. The corneas were then dehydrated topically with a 20% dextran solution for another hour, and the OCE measurements were repeated. A finite element method was used to quantify the Young's modulus of the corneas based on the OCE measurements.

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SUBMITTER: Singh M 

PROVIDER: S-EPMC6097919 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature