Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease.

ABSTRACT:

Introduction

Neuroimaging modalities can measure different aspects of the disease process in Alzheimer's disease, although the relationship between these modalities is unclear.

Methods

We assessed subject-level regional correlations between tau on [¹⁸F]AV-1451 positron emission tomography (PET), β amyloid on Pittsburgh compound B PET, hypometabolism on [¹⁸F] fluorodeoxyglucose PET, and cortical thickness on magnetic resonance imaging in 96 participants with typical and atypical Alzheimer's disease presentations. We also assessed how correlations between modalities varied according to age, presenting syndrome, tau-PET severity, and asymmetry.

Results

[¹⁸F]AV-1451 uptake showed the strongest regional correlation with hypometabolism. Corr

SUBMITTER: Whitwell JL 

PROVIDER: S-EPMC6097955 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature