Pre-treatment with sumatriptan for cilostazol induced headache in healthy volunteers.

ABSTRACT:

Background

Previous studies indicate that sumatriptan is not effective when second messenger levels are high as after cilostazol provocation. Therefore, we have conducted the present study, where sumatriptan is administrated as pretreatment before cAMP increases due to cilostazol intake. Our hypothesis was that pretreatment with sumatriptan would have a significant effect against cilostazol induced headache in healthy volunteers.

Methods

In a double-blind, randomized, crossover design, 30 healthy volunteers of both sexes received cilostazol 200 mg on two separate days, each day preceded by oral sumatriptan (2 × 50 mg) or placebo. Headache response and accompanying symptoms were registered in a questionnaire by the participants themselves.

Results

Cilostazol induced a

SUBMITTER: Falkenberg K 

PROVIDER: S-EPMC6097976 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature