The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects.

ABSTRACT: The ability of ketamine administration to activate prefrontal glutamate neurotransmission is thought to be a key mechanism contributing to its transient psychotomimetic effects and its delayed and sustained antidepressant effects. Rodent studies employing carbon-13 magnetic resonance spectroscopy (¹³C MRS) methods have shown ketamine and other N-methyl-D-aspartate (NMDA) receptor antagonists to transiently increase measures reflecting glutamate-glutamine cycling and glutamate neurotransmission in the frontal cortex. However, there are not yet direct measures of glutamate neurotransmission in vivo in humans to support these hypotheses. The current first-level pilot study employed a novel prefrontal ¹³C MRS approach similar to that used in the rodent studies for direct

SUBMITTER: Abdallah CG 

PROVIDER: S-EPMC6098048 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature