AIEC infection triggers modification of gut microbiota composition in genetically predisposed mice, contributing to intestinal inflammation.

ABSTRACT: A high prevalence of adherent-invasive E. coli (AIEC) in the intestinal mucosa of Crohn's disease patients has been shown. AIEC colonize the intestine and induce inflammation in genetically predisposed mouse models including CEABAC10 transgenic (Tg) mice expressing human CEACAM6-receptor for AIEC and eif2ak4^-/- mice exhibiting autophagy defect in response to AIEC infection. Here, we aimed at investigating whether gut microbiota modification contributes to AIEC-induced intestinal inflammation in these mouse models. For this, eif2ak4^+/+ and eif2ak4^-/- mice or CEABAC10 Tg mice invalidated for Eif2ak4 gene (Tg/eif2ak4^-/-) or not (Tg/eif2ak4^+/+) were infected with the AIEC reference strain LF82 or the non-pathogenic E. coli K12 MG1655 strai

SUBMITTER: Bretin A 

PROVIDER: S-EPMC6098085 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature