Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank.

ABSTRACT: Mosaic loss of the Y chromosome (mLOY) is the most commonly reported large structural somatic event. Previous studies have indicated age and cigarette smoking increase the risk of mLOY, but the relationship of other exposures with mLOY and mLOY with disease has not been adequately investigated. We characterized mLOY in a large cohort of 223,338 men from the UK Biobank by scanning for deviations in genotyping array median log₂ intensity ratios (mLRR) of the Y chromosome using a standard algorithm. A total of 3,789 (1.7%) men showed evidence for mLOY (mLRR < -0.15). In multivariable-adjusted logistic regression models, we found that mLOY increases exponentially with age (overall P-value < 4.9 × 10^-324; p-value for the quadratic term = 2.1 × 10^-7), and observe

SUBMITTER: Loftfield E 

PROVIDER: S-EPMC6098142 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature