A Comparison of Oxidative Lactate Metabolism in Traumatically Injured Brain and Control Brain.

ABSTRACT: Metabolic abnormalities occur after traumatic brain injury (TBI). Glucose is conventionally regarded as the major energy substrate, although lactate can also be an energy source. We compared 3-¹³C lactate metabolism in TBI with "normal" control brain and muscle, measuring ¹³C-glutamine enrichment to assess tricarboxylic acid (TCA) cycle metabolism. Microdialysis catheters in brains of nine patients with severe TBI, five non-TBI brain surgical patients, and five resting muscle (non-TBI) patients were perfused (24 h in brain, 8 h in muscle) with 8 mmol/L sodium 3-¹³C lactate. Microdialysate analysis employed ISCUS and nuclear magnetic resonance. In TBI, with 3-¹³C lactate perfusion, microdialysate glucose concentration increased nonsignificantly (m

SUBMITTER: Jalloh I 

PROVIDER: S-EPMC6098406 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature