Identification of key genes and pathways involved in response to pain in goat and sheep by transcriptome sequencing.

ABSTRACT:

Purpose

This aim of this study was to investigate the key genes and pathways involved in the response to pain in goat and sheep by transcriptome sequencing.

Methods

Chronic pain was induced with the injection of the complete Freund's adjuvant (CFA) in sheep and goats. The animals were divided into four groups: CFA-treated sheep, control sheep, CFA-treated goat, and control goat groups (n = 3 in each group). The dorsal root ganglions of these animals were isolated and used for the construction of a cDNA library and transcriptome sequencing. Differentially expressed genes (DEGs) were identified in CFA-induced sheep and goats and gene ontology (GO) enrichment analysis was performed.

Results

In total, 1748 and 2441 DEGs were identified in CFA-treated goat and sheep, respe

SUBMITTER: Deng X 

PROVIDER: S-EPMC6098572 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature