The phenomena of balanced effect between α-globin gene and of β-globin gene.

ABSTRACT: BACKGROUND:Thalassemias (TM) are the most common autosomal recessive disorders in Southeast Asian countries. Both α- and β-thalassemia lead to a decrease or absence of globin chains. The most serious of the thalassemia syndromes is thalassemia major which is characterized by a transfusion dependent anemia and subsequent iron overload caused by repeated blood transfusions. It is preventive by genotyping the parents. A better understanding of the laboratory data will help provide an accurate diagnosis of thalassemia major, and prevention and controlling programs in routine laboratories. CASE PRESENTATION:The patient was a one-year-old boy born to non-consanguineous parents. He was referred to our outpatient clinic for hemolytic anemia after a cold. Hematological investigations revealed sever

SUBMITTER: Zhong L 

PROVIDER: S-EPMC6098578 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature