Dysregulation of the calcium handling protein, CCDC47, is associated with diabetic cardiomyopathy.

ABSTRACT:

Background

Diabetes mellitus is associated with an increased risk in diabetic cardiomyopathy (DCM) that is distinctly not attributed to co-morbidities with other vasculature diseases. To date, while dysregulation of calcium handling is a key hallmark in cardiomyopathy, studies have been inconsistent in the types of alterations involved. In this study human cardiomyocytes were exposed to an environmental nutritional perturbation of high glucose, fatty acids, and l-carnitine to model DCM and iTRAQ-coupled LC-MS/MS proteomic analysis was used to capture proteins affected by the perturbation. The proteins captured were then compared to proteins currently annotated in the cardiovascular disease (CVD) gene ontology (GO) database to identify proteins not previously described as being rela

SUBMITTER: Thapa K 

PROVIDER: S-EPMC6098598 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature