Note on the use of different approaches to determine the pore sizes of tissue engineering scaffolds: what do we measure?

ABSTRACT:

Background

Collagen-based scaffolds provide a promising option for the treatment of bone defects. One of the key parameters of such scaffolds consists of porosity, including pore size. However, to date, no agreement has been found with respect to the methodology for pore size evaluation. Since the determination of the exact pore size value is not possible, the comparison of the various methods applied is complicated. Hence, this study focuses on the comparison of two widely-used methods for the characterization of porosity-scanning electron microscopy (SEM) and micro-computed tomography (micro-CT).

Methods

7 types of collagen-based composite scaffold models were prepared by means of lyophilization and collagen cross-linking. Micro-CT analysis was performed in 3D and in 2D (p

SUBMITTER: Bartos M 

PROVIDER: S-EPMC6098612 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature