Functional outcomes in adults with tuberculous meningitis admitted to the ICU: a multicenter cohort study.

ABSTRACT:

Background

Tuberculous meningitis (TBM) is a devastating infection in tuberculosis endemic areas with limited access to intensive care. Functional outcomes of severe adult TBM patients admitted to the ICU in nonendemic areas are not known.

Methods

We conducted a retrospective multicenter cohort study (2004-2016) of consecutive TBM patients admitted to 12 ICUs in the Paris area, France. Clinical, biological, and brain magnetic resonance imaging (MRI) findings at admission associated with a poor functional outcome (i.e., a score of 3-6 on the modified Rankin scale (mRS) at 90 days) were identified by logistic regression. Factors associated with 1-year mortality were investigated by Cox proportional hazards modeling.

Results

We studied 90 patients, of whom 61 (68%) had a

SUBMITTER: Cantier M 

PROVIDER: S-EPMC6098613 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature