Balanced crystalloids versus isotonic saline in critically ill patients: systematic review and meta-analysis.

ABSTRACT:

Objectives

Intravenous fluids are one of the most used medical therapy for patients, especially critically ill patients. We conducted a meta-analysis comparing between balanced crystalloids and normal saline in critically ill patients and its effect on various clinical outcomes.

Design

Meta-analysis and systematic review of randomized clinical trials (RCTs).

Methods and data source

Electronic search was performed using PubMed, Cochrane library, and clinical trials.gov from inception through March 1, 2018, with inclusion of prospective studies that investigated one of the primary outcomes which were acute kidney injury (AKI) and in-hospital mortality while secondary outcomes were intensive care unit (ICU) mortality and new renal replacement therapy (RRT).

Results

SUBMITTER: Zayed YZM 

PROVIDER: S-EPMC6098635 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature