Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumors.

ABSTRACT:

Background

Ovarian cancer is a complicated malady associated with cancer stem cells (CSCs) contributing to 238,700 estimated new cases and 151,900 deaths per year, worldwide. CSCs comprise a tiny fraction of tumor-bulk responsible for cancer recurrence and eventual mortality. CSCs or tumor initiating cells are responsible for self-renewal, differentiation and proliferative potential, tumor initiation capability, its progression, drug resistance and metastatic spread. Although several biomarkers are implicated in these processes, their distribution within the ovary and association with single cell type has neither been established nor demonstrated across ovarian tumor developmental stages. Therefore, precise identification, thorough characterization and effective targeted destructio

SUBMITTER: Parte SC 

PROVIDER: S-EPMC6098829 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature