Ensheathing cells utilize dynamic tiling of neuronal somas in development and injury as early as neuronal differentiation.

ABSTRACT:

Background

Glial cell ensheathment of specific components of neuronal circuits is essential for nervous system function. Although ensheathment of axonal segments of differentiated neurons has been investigated, ensheathment of neuronal cell somas, especially during early development when neurons are extending processes and progenitor populations are expanding, is still largely unknown.

Methods

To address this, we used time-lapse imaging in zebrafish during the initial formation of the dorsal root ganglia (DRG).

Results

Our results show that DRG neurons are ensheathed throughout their entire lifespan by a progenitor population. These ensheathing cells dynamically remodel during development to ensure axons can extend away from the neuronal cell soma into the CNS and out

SUBMITTER: Nichols EL 

PROVIDER: S-EPMC6098834 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature