Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot.

ABSTRACT:

Objective

Due to the localized nature of Charcot foot, systemically altered levels of inflammation markers can be difficult to measure. The aim of this study was to investigate whether it is possible to detect an arteriovenous (A-V) flux in any locally produced inflammatory biomarkers from an acute Charcot foot by comparing local and systemic measurements.

Methods

We included patients with acute diabetic Charcot foot. Blood was sampled from the vena saphena magna on the distal part of the crus bilaterally as well as from the arteria radialis. To minimize the A-V shunting effect, the feet were externally cooled with ice water prior to resampling.

Results

Both before and after cooling, the A-V flux of interleukin-6 (IL-6) between the Charcot feet and the arterial level

SUBMITTER: Jansen RB 

PROVIDER: S-EPMC6098852 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature