Lipoprotein lipase gene polymorphisms as risk factors for stroke: a computational and meta-analysis.

ABSTRACT:

Objectives

Stroke is the most common neurological disorder and genetic susceptibility has an important role in its etiology. Polymorphism in several genes such as lipoprotein lipase (LPL) is propounded as a risk for stroke. This meta-analysis investigated the association of rs285 and rs320 LPL polymorphism with stroke risk.

Materials and methods

We searched PubMed, Clarivate Analytics Web of Science, Google Scholar, and Science Direct databases for appropriate studies. The odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of this association. Also, the effects of four common polymorphisms (rs268, rs285, rs320, and rs328) on the molecular aspects of LPL were evaluated by in silico tools. Five studies were included in

SUBMITTER: Nejati M 

PROVIDER: S-EPMC6098956 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature