Synthetic efforts towards the stereoselective synthesis of NF00659B₁.

ABSTRACT: NF00659B₁ is a novel α-pyrone diterpenoid natural product with potent anti-colon cancer activity. A stereoselective approach to the 2,2-dimethyl oxepanol core of NF00659B₁ is described enlisting a sequence of olefinic ester ring-closing metathesis, epoxidation, and Grignard addition. This strategy paves the way to a total synthesis of NF00659B₁ for further biological studies.

SUBMITTER: Kwon DY 

PROVIDER: S-EPMC6098985 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature