Mechanism Sharing Between Genetic and Gestational Hypoxia-Induced Cardiac Anomalies.

ABSTRACT: Background: Cardiac development is a dynamic process both temporally and spatially. These complex processes are often disturbed and lead to congenital cardiac anomalies that affect approximately 1% of live births. Disease-causing variants in several genetic loci lead to cardiac anomalies, with variants in transcription factor NKX2-5 gene being one of the largest variants known. Gestational hypoxia, such as seen in high-altitude pregnancy, has been known to affect cardiac development, yet the incidence and underlying mechanisms are largely unknown. Methods and Results: Normal wild-type female mice mated with heterozygous Nkx2-5 mutant males were housed under moderate hypoxia (14% O₂) or normoxia (20.9% O₂) conditions from 10.5 days of gestat

SUBMITTER: Moumne O 

PROVIDER: S-EPMC6099185 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature