Cytokine expression profile in the bone-anchored hearing system: 12-week results from a prospective randomized, controlled study.

ABSTRACT:

Objective

To study the effect of implanting the percutaneous bone-anchored hearing system (BAHS) itself and inflammation of the peri-abutment skin warrant clarification. In this study, we aimed to acquire further insight into the immune responses related to BAHS surgery and peri-implant skin inflammation.

Materials and methods

During surgery and 12 weeks post-implantation, skin biopsies were obtained. If applicable, additional biopsies were taken during cases of inflammation. The mRNA expression of IL-1β, IL-6, IL-8, TNFα, IL-17, IL-10, TGF-ß, MIP-1α, MMP-9, TIMP-1, COL1α1, VEGF-A, FGF-2 TLR-2, and TLR-4 was quantified using qRT-PCR.

Results

Thirty-five patients agreed to the surgery and 12-week biopsy. Twenty-two patients had mRNA of sufficient quality for analysis.

SUBMITTER: Calon TGA 

PROVIDER: S-EPMC6099213 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature