Adiposity and breast cancer risk in postmenopausal women: Results from the UK Biobank prospective cohort.

ABSTRACT: Body size is an important modifiable risk factor for postmenopausal breast cancer. However, it remains unclear whether direct measures of fat mass are better indicators of risk than anthropometric measures, or whether central adiposity may contribute to risk beyond overall adiposity. We analyzed data from 162,691 postmenopausal women in UK Biobank followed from 2006 to 2014. Body size was measured by trained technicians. Multivariable-adjusted Cox regression was used to estimate relative risks. Analyses were stratified by age at recruitment, region and socioeconomic status, and adjusted for family history of breast cancer, age at menarche, age at first birth, parity, age at menopause, previous hormone replacement therapy use, smoking, alcohol intake, height, physical activity and ethnicity

SUBMITTER: Guo W 

PROVIDER: S-EPMC6099222 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature