Atopy-Dependent and Independent Immune Responses in the Heightened Severity of Atopics to Respiratory Viral Infections: Rat Model Studies.

ABSTRACT: Allergic (Th2^high immunophenotype) asthmatics have a heightened susceptibility to common respiratory viral infections such as human rhinovirus. Evidence suggests that the innate interferon response is deficient in asthmatic/atopic individuals, while other studies show no differences in antiviral response pathways. Unsensitized and OVA-sensitized/challenged Th2^high (BN rats) and Th2^low immunophenotype (PVG rats) animals were inoculated intranasally with attenuated mengovirus (vMC₀). Sensitized animals were exposed/unexposed during the acute viral response phase. Cellular and transcriptomic profiling was performed on bronchoalveolar lavage cells. In unsensitized PVG rats, vMC₀ elicits a prototypical antiviral response (neutrophilic airwa

SUBMITTER: Lauzon-Joset JF 

PROVIDER: S-EPMC6099265 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature