Predicting mammalian metabolism and toxicity of pesticides in silico.

ABSTRACT: Pesticides must be effective to be commercially viable but they must also be reasonably safe for those who manufacture them, apply them, or consume the food they are used to produce. Animal testing is key to ensuring safety, but it comes late in the agrochemical development process, is expensive, and requires relatively large amounts of material. Surrogate assays used as in vitro models require less material and shift identification of potential mammalian toxicity back to earlier stages in development. Modern in silico methods are cost-effective complements to such in vitro models that make it possible to predict mammalian metabolism, toxicity and exposure for a pesticide, crop residue or other metabolite before it has been synthesized. Their broader use could substantially reduce the amou

SUBMITTER: Clark RD 

PROVIDER: S-EPMC6099302 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature