Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal.

ABSTRACT: Cannabidiol (CBD), a non-intoxicating cannabinoid found in cannabis, may be a promising novel smoking cessation treatment due to its anxiolytic properties, minimal side effects and research showing that it may modify drug cue salience. We used an experimental medicine approach with dependent cigarette smokers to investigate if (1) overnight nicotine abstinence, compared with satiety, will produce greater attentional bias (AB), higher pleasantness ratings of cigarette-related stimuli and increased craving and withdrawal; and (2) CBD in comparison to placebo, would attenuate AB, pleasantness of cigarette-related stimuli, craving and withdrawal and not produce any side effects. Randomized, double-blind cross-over study with a fixed satiated session followed by two overnight abstinent sessions

SUBMITTER: Hindocha C 

PROVIDER: S-EPMC6099309 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature