Increased susceptibility to oral Trichuris muris infection in the specific absence of CXCR5⁺ CD11c⁺ cells.

ABSTRACT: Trichuris muris is a natural mouse helminth pathogen which establishes infection specifically in the caecum and proximal colon. The rapid expulsion of T. muris in resistant mouse strains is associated with the induction of a protective T helper cell type 2 (Th2)-polarized immune response. Susceptible mouse strains, in contrast, mount an inappropriate Th1 response to T. muris infection. Expression of the chemokine CXCL13 by stromal follicular dendritic cells attracts CXCR5-expressing cells towards the B-cell follicles. Previous studies using a complex in vivo depletion model have suggested that CXCR5-expressing conventional dendritic cells (cDC) help regulate the induction of Th2-polarized responses. Here, transgenic mice with CXCR5 deficiency specifically restricted to CD11c⁺ ce

SUBMITTER: Bradford BM 

PROVIDER: S-EPMC6099414 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature