Randomised clinical trial: 2% taurolidine versus 0.9% saline locking in patients on home parenteral nutrition.

ABSTRACT:

Background

The catheter lock solutions 2% taurolidine and 0.9% saline are both used to prevent catheter-related bloodstream infections (CRBSIs) in home parenteral nutrition patients.

Aims

To compare the effectiveness and safety of taurolidine and saline.

Methods

This multicentre double-blinded trial randomly assigned home parenteral nutrition patients to use either 2% taurolidine or 0.9% saline for 1 year. Patients were stratified in a new catheter group and a pre-existing catheter group. Primary outcome was the rate of CRBSIs/1000 catheter days in the new catheter group and pre-existing catheter group, separately.

Results

We randomised 105 patients, of which 102 were analysed as modified intention-to-treat population. In the new catheter group, rates of CRBSIs

SUBMITTER: Wouters Y 

PROVIDER: S-EPMC6099431 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature