Magnetic Resonance Imaging for Quantitative Assessment of Lung Aeration: A Pilot Translational Study.

ABSTRACT: Background: Computed tomography is the gold standard for lung aeration assessment, but exposure to ionizing radiation limits its application. We assessed the ability of magnetic resonance imaging (MRI) to detect changes in lung aeration in ex vivo isolated swine lung and the potential of translation of the findings to human MRI scans. Methods: We performed MRI scans in 11 isolated non-injured and injured swine lungs, as well as 6 patients both pre- and post-operatively. Images were obtained using a 1.5 T MRI scanner, with T₁ - weighted volumetric interpolated breath-hold examination (VIBE) and T₂ - weighted half-Fourier acquisition single-shot turbo spin-echo (HASTE) sequences. We scanned swine lungs, with reference samples of water and muscle, at

SUBMITTER: Ball L 

PROVIDER: S-EPMC6099446 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature