NTyroSite: Computational Identification of Protein Nitrotyrosine Sites Using Sequence Evolutionary Features.

ABSTRACT: Nitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species. As an indicator of cell damage and inflammation, protein nitrotyrosine serves to reveal biological change associated with various diseases or oxidative stress. Accurate identification of nitrotyrosine site provides the important foundation for further elucidating the mechanism of protein nitrotyrosination. However, experimental identification of nitrotyrosine sites through traditional methods are laborious and expensive. In silico prediction of nitrotyrosine sites based on protein sequence information are thus highly desired. Here, we report a novel predictor, NTyroSite, for accurate prediction of nitrotyrosine sites using sequence evolutionary information. The generated features were optimized using a

SUBMITTER: Hasan MM 

PROVIDER: S-EPMC6099560 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature