Adaptive deletion in resistance gene duplications in the malaria vector Anopheles gambiae.

ABSTRACT: While gene copy-number variations play major roles in long-term evolution, their early dynamics remains largely unknown. However, examples of their role in short-term adaptation are accumulating: identical repetitions of a locus (homogeneous duplications) can provide a quantitative advantage, while the association of differing alleles (heterogeneous duplications) allows carrying two functions simultaneously. Such duplications often result from rearrangements of sometimes relatively large chromosome fragments, and even when adaptive, they can be associated with deleterious side effects that should, however, be reduced by subsequent evolution. Here, we took advantage of the unique model provided by the malaria mosquito Anopheles gambiae s.l. to investigate the early evolution of sever

SUBMITTER: Assogba BS 

PROVIDER: S-EPMC6099818 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature