Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm.

ABSTRACT: The transmission of HIV can be prevented by the application of neutralizing monoclonal antibodies and lectins. Traditional recombinant protein manufacturing platforms lack sufficient capacity and are too expensive for developing countries, which suffer the greatest disease burden. Plants offer an inexpensive and scalable alternative manufacturing platform that can produce multiple components in a single plant, which is important because multiple components are required to avoid the rapid emergence of HIV-1 strains resistant to single microbicides. Furthermore, crude extracts can be used directly for prophylaxis to avoid the massive costs of downstream processing and purification. We investigated whether rice could simultaneously produce three functional HIV-neutralizing proteins (the monoc

SUBMITTER: Vamvaka E 

PROVIDER: S-EPMC6099877 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature