Osterix functions downstream of anti-Mullerian hormone signaling to regulate Mullerian duct regression.

ABSTRACT: In mammals, the developing reproductive tract primordium of male and female fetuses consists of the Wolffian duct and the Müllerian duct (MD), two epithelial tube pairs surrounded by mesenchyme. During male development, mesenchyme-epithelia interactions mediate MD regression to prevent its development into a uterus, oviduct, and upper vagina. It is well established that transforming growth factor-β family member anti-Müllerian hormone (AMH) secreted from the fetal testis and its type 1 and 2 receptors expressed in MD mesenchyme regulate MD regression. However, little is known about the molecular network regulating downstream actions of AMH signaling. To identify potential AMH-induced genes and regulatory networks controlling MD regression in a global nonbiased manner, we examined transcrip

SUBMITTER: Mullen RD 

PROVIDER: S-EPMC6099909 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature