Knowledge-Based Neuroendocrine Immunomodulation (NIM) Molecular Network Construction and Its Application.

ABSTRACT: Growing evidence shows that the neuroendocrine immunomodulation (NIM) network plays an important role in maintaining and modulating body function and the homeostasis of the internal environment. The disequilibrium of NIM in the body is closely associated with many diseases. In the present study, we first collected a core dataset of NIM signaling molecules based on our knowledge and obtained 611 NIM signaling molecules. Then, we built a NIM molecular network based on the MetaCore database and analyzed the signaling transduction characteristics of the core network. We found that the endocrine system played a pivotal role in the bridge between the nervous and immune systems and the signaling transduction between the three systems was not homogeneous. Finally, employing the forest algorithm, w

SUBMITTER: Wang T 

PROVIDER: S-EPMC6099962 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature